PUBLICATIONS

The Pentelute Lab leverages expertise in peptide chemistry, molecular biology, and technology development to create peptide and protein-based therapeutics and tools for chemical biology.

Pentelute Lab, MIT, Cambridge, Chemistry, Molecular biology, technology development, peptide, protein-based therapeutics, chemical Biology, Bradley Pentelute

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PUBLICATIONS

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2024
Publications

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Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders

2024, Publications

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Investigation of commercially available resins for the automated flow synthesis of difficult or long peptide sequences

2024, Publications

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Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: A new approach to prevent and treat bacterial infections

2023, Publications

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Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6

2023, Publications

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Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells

2023, Publications

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Automated Fast-Flow Synthesis of Chromosome 9 Open Reading Frame 72 Dipeptide Repeat Proteins

2023, Publications

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Rapid Chemical Synthesis of Serine Protease Inhibitor Kazal-type 13 (SPINK13) Glycoform by a Combined Method with Glycan Insertion Strategy and Fast-Flow Fmoc SPPS

2023, Publications

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Branched Multimeric Peptides as Affinity Reagents for the Detection of α-Klotho Protein

2023, Publications

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Rapid Single-Shot Synthesis of the 214 Amino Acid-Long N-Terminal Domain of Pyocin S2

2023, Publications

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In-Cell Penetration Selection–Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery

2023, Publications

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Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis

2023, Publications

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A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma

2022, Publications

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Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

2022, Publications

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A Tumor-Homing Peptide Platform Enhances Drug Solubility, Improves Blood–Brain Barrier Permeability and Targets Glioblastoma

2022, Publications

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Total synthesis of himastatin

2022, Publications

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Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions

2022, Publications

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Palladium Mediated Synthesis of Protein–Polyarene Conjugates

2022, Publications

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Palladium-Mediated Incorporation of Carboranes into Small Molecules, Peptides, and Proteins

2022, Publications

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Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity

2022, Publications

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Automated Flow Synthesis of Peptide–PNA Conjugates

2022, Publications

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Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design

2022, Publications

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Palladium–peptide oxidative addition complexes for bioconjugation

2022, Publications

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Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons

2022, Publications

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Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2

2022, 2022, Publications

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Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers

2021, Publications

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Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription

2021, Publications

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Automated affinity selection for rapid discovery of peptide binders

2021, Publications

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An in vivo selection-derived D-peptide for engineering erythrocyte-binding antigens that promote immune tolerance

2021, Publications

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Deep learning to design nuclear-targeting abiotic miniproteins

2021, Publications

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Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents

2021, Publications

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Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

2021, Publications

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Selective N-Arylation of p-Aminophenylalanine in Unprotected Peptides with Organometallic Palladium Reagents

2021, Publications

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Targeting Glioblastoma Using a Novel Peptide Specific to a Deglycosylated Isoform of Brevican

2021, Publications

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Oligonucleotide Bioconjugation with Bifunctional Palladium Reagents

2021, Publications

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A reactive peptide interface for site-selective cysteine bioconjugation

2021, Publications

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Identification of N-Terminally Diversified GLP-1R Agonists Using Saturation Mutagenesis and Chemical Design

2021, Publications

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Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

2021, Publications

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IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells

2021, Publications

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De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein

2021, Publications

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Palladium–Protein Oxidative Addition Complexes by Amine-Selective Acylation

2020, Publications

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Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis

2020, Publications

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Discovery of Nucleic Acid Binding Molecules from Combinatorial Biohybrid Nucleobase Peptide Libraries

2020, Publications

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Anthrax Protective Antigen Retargeted with Single-Chain Variable Fragments Delivers Enzymes to Pancreatic Cancer Cells

2020, Publications

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Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release

2020, Publications

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A Platinum(IV) Prodrug—Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain

2020, Publications

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Conformational Dynamics in Extended RGD-Containing Peptides

2020, Publications

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Ultra-large chemical libraries for the discovery of high-affinity peptide binders

2020, Publications

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Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids

2020, Publications

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Synthesis of proteins by automated flow chemistry

2020, Publications

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Protein–Protein Cross-Coupling via Palladium–Protein Oxidative Addition Complexes from Cysteine Residues

2020, Publications

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Efficient Flow Synthesis of Human Antimicrobial Peptides

2020, Publications

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A novel, safe, fast and efficient treatment for Her2‐positive and negative bladder cancer utilizing an EGF‐anthrax toxin chimera

2019, Publications

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Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism

2020, Publications

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Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy

2020, Publications

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Quantifying residue-specific conformational dynamics of a highly reactive 29-mer peptide

2020, Publications

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Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

2019, Publications

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Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy

2019, Publications

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Studies on a landscape of perfluoroaromatic-reactive peptides

2019, Publications

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In-solution enrichment identifies peptide inhibitors of protein–protein interactions

2019, Publications

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Conformational Stabilization and Rapid Labeling of a 29-Residue Peptide by a Small Molecule Reaction Partner

2019, Publications

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Affinity-based capture and identification of protein effectors of the growth regulator ppGpp

2019, Publications

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Arylation Chemistry for Bioconjugation

2019, Publications

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A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

2019, Publications

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Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

2018, Publications

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Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy

2018, Publications

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Antibody–Bactericidal Macrocyclic Peptide Conjugates To Target Gram‐Negative Bacteria

2018, Publications

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Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription

2018, Publications

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Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability

2018, Publications

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Xenoprotein engineering via synthetic libraries

2018, Publications

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Amide-forming chemical ligation via O-acyl hydroxamic acids

2018, Publications

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Designing Well-Structured Cyclic Pentapeptides Based on Sequence–Structure Relationships

2018, Publications

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Site‐Selective Cysteine–Cyclooctyne Conjugation

2018, Publications

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Perfluoroaryl Bicyclic Cell‐Penetrating Peptides for Delivery of Antisense Oligonucleotides

2018, Publications

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Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery

2018, Publications

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Palladium Oxidative Addition Complexes for Peptide and Protein Cross-linking

2018, Publications

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Discovery of a 29-Amino-Acid Reactive Abiotic Peptide for Selective Cysteine Arylation

2018, Publications

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A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylation

2017, Publications

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Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR

2017, Publications

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Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier

2017, Publications

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Heterochiral Knottin Protein: Folding and Solution Structure

2017, Publications

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Library Design-Facilitated High-Throughput Sequencing of Synthetic Peptide Libraries

2017, Publications

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Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions

2017, Publications

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Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

2017, Publications

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Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase

2017, Publications

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Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

2017, Publications

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A fully automated flow-based approach for accelerated peptide synthesis

2017, Publications

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Palladium-Mediated Arylation of Lysine in Unprotected Peptides

2017, Publications

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Salt Effect Accelerates Site-Selective Cysteine Bioconjugation

2016, Publications

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d-Amino Acid Scan of Two Small Proteins

2016, Publications

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Nitrogen Arylation for Macrocyclization of Unprotected Peptides

2016, Publications

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Delivery of Non-Native Cargo into Mammalian Cells Using Anthrax Lethal Toxin

2016, Publications

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Systematic Investigation of EDC/sNHS-Mediated Bioconjugation Reactions for Carboxylated Peptide Substrates

2016, Publications

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C-Terminal Modification of Fully Unprotected Peptide Hydrazides via in Situ Generation of Isocyanates

2016, Publications

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Macrocyclization of Unprotected Peptide Isocyanates

2016, Publications

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A perfluoroaromatic abiotic analog of H2 relaxin enabled by rapid flow-based peptide synthesis

2016, Publications

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π-Clamp-mediated cysteine conjugation

2015, Publications

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A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway

2015, Publications

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Organometallic palladium reagents for cysteine bioconjugation

2015, Publications

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An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides.

2015, Publications

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Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen

2015, Publications

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A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

2015, Publications

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Atomic structure of anthrax protective antigen pore elucidates toxin translocation.

2015, Publications

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Total Synthesis and Biochemical Characterization of Mirror Image Barnase

2015, Publications

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Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs

2015, Publications

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Delivery of mirror image polypeptides into cells

2014, Publications

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Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen

2014, Publications

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Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides

2014, Publications

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Flow-Based Enzymatic Ligation via Sortase A

2014, Publications

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Rapid Total Synthesis of DARPin pE59 and Barnase

2014, Publications

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Rapid Flow-Based Peptide Synthesis

2014, Publications

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Convergent Diversity-Oriented Side-Chain Macrocyclization Scan for Unprotected Polypeptides

2014, Publications

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Enzymatic “Click” Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferase

2013, Publications

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Monitoring the Kinetics of the pH-Driven Transition of the Anthrax Toxin Prepore to the Pore by Biolayer Interferometry and Surface Plasmon Resonance.

2013, Publications

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A Perfluoroaryl-Cysteine Chemistry Approach to Unprotected Peptide Stapling

2013, Publications

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Three Dimensional Structure of the Anthrax Toxin Translocon–lethal Factor Complex by Cryo-electron Microscopy

2013, Publications

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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

2013, Publications

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Assembly of Anthrax Toxin Pore: Lethal-factor Complexes into Lipid Nanodiscs.

2013, Publications

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Protein Thioester Synthesis Enabled By: Sortase

2012, Publications